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Canine Phosphofructokinase (PFK) Deficiency
(provide by SpanielsOnline.com) |
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Canine Phosphofructokinase (PFK) Deficiency is an
autosomal recessive genetic disease that inhibits a spaniel's ability to convert
sugar into energy. Spaniels affected by PFK will often exhibit signs of exercise
intolerance. Additionally, PFK destroys the red blood cells that deliver oxygen
and remove waste throughout the spaniel's body. This destruction of red blood
cells causes the dog to become mildly or moderately anemic and also shows signs
of exercise intolerance. A simple blood test by your veterinarian is all that is
required to test for PFK. Results from a PFK test will yield one of three
possible outcomes: normal/clear, affected, or a carrier. A spaniel that tests
"Normal/Clear" indicates that s/he does not carry the PFK deficiency and cannot
pass it on to his or her offspring when bred to another PFK Normal/Clear
spaniel. A spaniel that tests "Affected" will show outward signs of exercise
intolerance and will not be able to tolerate the physical demands placed on
him/her in the field. A "Carrier" of the disease shows no outward signs of the
PFK deficiency, but can pass it on to their offspring when bred. The only
sure-fire way to prevent to proliferation of PFK through breeding is to test
both the sire and dam prior to breeding to ensure they are PFK Normal/Clear.
The results of the PFK test can be registered with the Orthopedic
Foundation for Animals (OFA). Further information about the OFA's Registry of
PFK Deficiency in Spaniels can be obtained by contacting:
The Orthopedic
Foundation for Animals,
2300 E. Nifong Boulevard,
Columbia, MO
65201-3856,
Phone (573) 442-0418.
Or visiting their website at www.offa.org
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